Hexadecan acid
Palmitic acid
CAS: 57-10-3
Molecular Formula: C16H32O2
Hexadecan acid - Names and Identifiers
| Name | Palmitic acid |
| Synonyms | NAA160 LunacP95 Neo-Fat16 LunacP95KC LoxiolEP278 Kortacid1698 Palmitic acid industrene4516 Hexadecan acid Hexadecanoic acid Palmitic acid tech palmitic acid, pure 1-Hexadecanoic acid Palmitic Acid (1.00509) pentadecanecarboxylicacid |
| CAS | 57-10-3 |
| EINECS | 200-312-9 |
| InChI | InChI=1/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18) |
| InChIKey | IPCSVZSSVZVIGE-UHFFFAOYSA-N |
Hexadecan acid - Physico-chemical Properties
| Molecular Formula | C16H32O2 |
| Molar Mass | 256.42 |
| Density | 0.852g/mLat 25°C(lit.) |
| Melting Point | 61-62.5°C(lit.) |
| Boling Point | 351.5 °C |
| Flash Point | >230°F |
| JECFA Number | 115 |
| Water Solubility | insoluble |
| Solubility | Insoluble in water, insoluble in cold ethanol, soluble in hot ethanol, ether, acetone, chloroform, petroleum ether. |
| Vapor Presure | 10 mm Hg ( 210 °C) |
| Appearance | The crystallizer in ethanol is a white crystalline waxy solid (white pearly phosphorus sheet) |
| Color | White or almost white |
| Merck | 14,6996 |
| BRN | 607489 |
| pKa | 4.78±0.10(Predicted) |
| Storage Condition | room temp |
| Stability | Stable. Combustible. Incompatible with bases, oxidizing agents, reducing agents. |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.4273 |
| MDL | MFCD00002747 |
| Physical and Chemical Properties | Characteristics of white with pearlescent phosphorus. melting point 63.1 ℃ boiling point 351.5 ℃ relative density 0.8388 solubility insoluble in water, slightly soluble in petroleum ether, soluble in ethanol. Soluble in ether, chloroform and acetic acid. |
| Use | Used as precipitant, chemical reagent and water-proofing agent |
Hexadecan acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36 - Irritating to the eyes R36/38 - Irritating to eyes and skin. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. |
| WGK Germany | - |
| RTECS | RT4550000 |
| TSCA | Yes |
| HS Code | 29157015 |
| Toxicity | LD50 i.v. in mice: 57±3.4 mg/kg (Or, Wretlind) |
Hexadecan acid - Upstream Downstream Industry
| Downstream Products | Isopropyl palmitate methyl hexadecanoate chloramphenicol palmitate Tween(R) 40 |
Hexadecan acid - Reference
| Reference Show more | 1. Zheng mangrong, LV Xiaoling, Wang Jianxin et al. Comparison of main components and antioxidant capacity of three kinds of sea buckthorn oil [J]. Food Research and Development 2018(8):24-29. 2. Ye Hao, Li Min, Zheng Bo, et al. Simultaneous determination of four kinds of fatty acids in the seeds of nanshiliu by GC [J]. Journal of Shenyang Pharmaceutical University 2020(3). 3. Ma Juanjuan, Han Na, Li qianlan et al. Preparation and characterization of ternary starch nanoparticles [J]. Food and Fermentation Technology 2018. 4. Cai Danhong, Xue Mei, Li Yu, Zhu Sirui, Liu Xiaoli, Zhang Liang. In vitro anti-nonalcoholic fatty liver disease activity of four main components contained in eucommia ulmoides leaves extract [J]. World Science and Technology-modernization of traditional Chinese medicine, 2021,23(01):81-87. 5. Wang, Tianyang, et al. "Metabologic profile indications of serum, lung, bronch of lavage fluid, split and feces in LPS-induced acute lung injury rats based on HPLC-ESI-QTOF-MS." Analytical and bioanalytical chemistry 412.5 (2020): 1215-1234. 6. [IF=5.64] Wu Dousheng et al."Oleanolic Acid Induces the Type III Secretion System of Ralstonia solanacearum."Front Microbiol. 2015 Dec;0:1466 7. [IF=3.125] Pengfei Liu et al."Effect of five saturated fatty acids on the properties of sweet-potato-starch-based films."J Appl Polym Sci. 2015 Feb;132(5): 8. [IF=9.229] Huan Xia et al."Enzymatic Cascade Reactions Mediated by Highly Efficient Biomimetic Quasi Metal-Organic Frameworks."Acs Appl Mater Inter. 2021;13(19):22240-22253 9. [IF=9.229] Chi Zhang et al."Fluorescent Cationic Conjugated Polymer-Based Adaptive Developing Strategy for Both Sebaceous and Blood Fingerprints."Acs Appl Mater Inter. 2021;13(23):27419-27429 10. [IF=9.229] Linlin Deng et al."Highly Crystalline Covalent Organic Frameworks Act as a Dual-Functional Fluorescent-Sensing Platform for Myricetin and Water, and Adsorbents for Myricetin."Acs Appl Mater Inter. 2021;13(28):33449-33463 11. [IF=9.147] Ling Huang et al."Dietary fatty acid-mediated protein encapsulation simultaneously improving the water-solubility, storage stability, and oral absorption of astaxanthin."Food Hydrocolloid. 2022 Feb;123:107152 12. [IF=6.057] Chenglong Sun et al."1,1′-binaphthyl-2,2′-diamine as a novel MALDI matrix to enhance the in situ imaging of metabolic heterogeneity in lung cancer."Talanta. 2020 Mar;209:120557 13. [IF=3] Qu Lala et al."Phenotypic assessment and ligand screening of ETA/ETB receptors with label-free dynamic mass redistribution assay."N-S Arch Pharmacol. 2020 Jun;393(6):937-950 14. [IF=2.984] Qiutong Chen et al."Maternal obesity alters circRNA expression and the potential role of mmu_circRNA_0000660 via sponging miR_693 in offspring liver at weaning age."Gene. 2020 Mar;731:144354 15. [IF=6.609] Min Lin et al."Product distribution-tuned and excessive hydrocracking inhibiting in fatty acid deoxygenation over amorphous Co@SiO2 porous nanorattles."Fuel. 2022 Jun;318:123605 |
Hexadecan acid - Nature
Open Data Verified Data
White with pearlescent scales. Melting point 63.1 °c. Boiling point 351.5 °c. The relative density was 0.8388. Insoluble in water, slightly soluble in petroleum ether, soluble in ethanol. Soluble in ether, chloroform and acetic acid.
Last Update：2025-06-10 22:55:16
Hexadecan acid - Preparation Method
Open Data Verified Data
The unsaturated fatty acid was isolated by vacuum distillation after hydrolysis of palm oil or palm oil, and then recrystallized.
Last Update：2022-01-01 10:31:13
Hexadecan acid - Introduction
Pharmacological effects: Mainly used as a surfactant. When used as a non-ionic type, it can be used for polyoxyethylene sorbitan monopalmitate and sorbitan monopalmitate. The former is made into an lipophilic emulsifier And used in all cosmetics and medicines, the latter can be used as an emulsifier for cosmetics, medicine, and food, a dispersant for pigment inks, and also as a defoamer; when used as an anion type, it is made into sodium palmitate and used as a raw material for fatty acid soap, plastic emulsifier, etc; zinc palmitate is used as a stabilizer for cosmetics and plastics; in addition to being used as a surfactant, it is also used as a raw material for isopropyl palmitate, methyl ester, butyl ester, amine compound, chloride, etc.; among them, isopropyl palmitate is a cosmetic oil phase raw material, which can be used to make lipstick, various creams, hair oils, hair pastes, etc.; others such as methyl palmitate can be used as lubricating oil additives, surfactant raw materials; PVC slip agents, etc; raw materials for candles, soap, grease, synthetic detergents, softeners, etc.; used as spices, are edible spices allowed by GB2760-1996 regulations in my country; also used as food defoamers.
Last Update：2022-10-16 17:26:29
Hexadecan acid - Application
Open Data Verified Data
raw materials for the production of soaps, candles, greases, softeners and synthetic detergents.
Last Update：2025-08-19 16:24:40
Hexadecan acid - Safety
Open Data Verified Data
- This product has low toxicity and irritation. Mice were injected intravenously with LD50 57mg/kg. The operator should wear protective gear.
- hard carton or woven bag lined with plastic bag, each box (or bag) net weight 25kg, 50kg. Store in a cool, dry, ventilated place, keep away from fire and oxidant. According to the general provisions of the storage and transportation of chemicals.
Last Update：2022-01-01 10:31:13
Hexadecan acid - Reference Information
| FEMA | 2832 | PALMITIC ACID |
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Overview | Ten acid also known as palmitic acid, at room temperature is a white crystal, insoluble in water, soluble in ether, chloroform, acetone and other organic solvents. Palmitic acid is one of the most widely distributed fatty acids in nature. It is widely found in various oils in the form of glycerides, such as tallow, palm oil, varnish, cottonseed oil, soybean oil, peanut oil, corn germ oil, fish oil, milk fat, cattle, sheep, pig fat, etc. It with higher saturated monohydric alcohol ester formation (I. E. Natural wax) widely exists in many kinds of animals and plants. |
| Application | a simple ester of palmitic acid, mainly used in the plastics industry. Its alkali metal salt is soluble in water and has a decontamination effect. It is one of the main components of soap and soap. Other metal salts are insoluble in water and are used in lubricants, pharmaceutical industry, cosmetics, water-proofing agents and fungicides. The main source of palmitic acid oil, oil saponification, acidification and separation. |
| Use | is mainly used as a surfactant, when used as a non-ionic, can be used for polyoxyethylene sorbitan monopalmitate and sorbitan monopalmitate, the former Made of lipophilic emulsifier used in all cosmetics and medicine, the latter can be used in cosmetics, medicine, food emulsifier, pigment ink dispersant, also used as defoaming agent; Used as anionic, made of sodium palmitate and raw materials for fatty acid soap, plastic emulsifier, etc.; Zinc palmitate used as a stabilizer for cosmetics, plastics; in addition to being used as a surfactant, it is also used as a raw material for isopropyl palmitate, methyl ester, butyl ester, amine compounds, chloride, etc. Among them, isopropyl palmitate is a raw material for cosmetic oil phase, which can be used for making lipstick, various creams, hair oil, hair Cream; Other such as methyl palmitate can be used as lubricating oil additives, surfactant raw materials; PVC slip agent; Candles, soap, grease, synthetic detergent, softener and other raw materials; Used as spices, is China's GB2760-1996 regulations allow the use of edible spices; Also used as food defoaming agent. used as precipitating agent, chemical reagent and water-repellent agent antifoaming agent; Raw material for producing other food additives (fatty acid glyceride, fatty acid sorbitan Ester, sugar Ester, etc.). Can also be used as a spice ingredient, according to FEMA regulations, the maximum amount of 1.0mg/kg in seasoning. raw materials for the production of candles, soaps, greases, softeners and synthetic detergents. Palmitic acid is used to make odorless chloramphenicol and various metal salts of palmitic acid, Its sodium salt or potassium salt can be used as emulsifier in emulsion polymerization, and aluminum salt and zinc salt are used in lubricant, paint, oil black and plasticizer. The product has a special aroma and taste, according to China's GB2760-89 regulations, can be used to prepare a variety of edible spices, but also used as a Defoamer and other food additives. used as reference material for gas phase analysis hardness of water and calcium, magnesium, barium, lead, mercury, zinc were measured. Organic Synthesis, manufacturing a variety of metal salts of palmitic acid and water repellent. A saturated fatty acid that targets the cell membrane. |
| production process | 1. Directly extracted from palm fruit; 2. With tallow (containing 50% palmitic acid), Wood wax (containing 77%) as raw materials, at high temperature (250 ℃), high pressure (50.67 × 105Pa) hydrolysis, can be prepared a mixture of a variety of fatty acids, after hydrolysis and alkaline treatment, the product can be obtained. With oleic acid as raw material, alkali fusion at 350 ℃, the double bond isomerization, and carboxyl group in the conjugated position, further catalytic oxidation, can be decomposed into palmitic acid. |
| toxicity | natural fatty acid, non-toxic. Safe for use in food (FDA,§ 172.860,2000). |
| production method | widely exists in nature, almost all oils have different content of palmitic acid component. China's specialty of black oil, palmitic acid content can be as high as 60%, and palm fruit palm oil content is about 40%, but the content of rapeseed oil is less than 2%. The oil or palm oil hydrolysis, fractionation, pressing separation of unsaturated fatty acids, after recrystallization of palmitic acid. Commercially available palmitic acid typically has a melting point of 57.5-62.5 °c. mixed fatty acids derived from rice bran oil, coconut oil, palm kernel oil and the like are subjected to vacuum fractionation. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 20:52:54
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